Subacute toxicity of ricazol as injection

Abstract

Subacute toxicity of Ricazol as injection, containing in 1 ml 100 mg Rico-bendazole is studied. The preparation in doses of 125 and 50 mg/kg at daily intro-duction during 7 days didn't cause deviations in behavior, consumption of forage and water, hematologic and biochemical indicators, mass coefficients of bodies, a functional condition of rats. Introduction Ricazol in a dose of 250 mg/kg reduced additional weights and body weight, caused oppression of animals and a case, changes of the main hematologic and biochemical indicators, including erythro-cytes, leukocytes, hemoglobin, bilirubin, urea and activity alanine aminotransfer-ase. The dose of ricazol of 250 mg/kg is toxic.

Keywords

• ricazol
• ricobendazole
• toxic properties
• rats
• biochemistry
• hematology