Кубанский научный медицинский вестник (May 2017)

PARATHYROID HORMONE-RELATED PROTEIN AND PROSTATE CANCER

  • V. L. MEDVEDEV,
  • E. A. STRYGINA,
  • A. N. KURZANOV

DOI
https://doi.org/10.25207/1608-6228-2017-1-145-154
Journal volume & issue
Vol. 1, no. 1
pp. 145 – 154

Abstract

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The survey presents the existing arguments and facts about the parathyroid hormone-related protein (PTHrP) and its role in pathophysiological and pathobio-chemical mechanisms that are related to onco-transformation of prostate. The para-thyroid hormone-related protein is a multipotent molecule, whose proteolytic proc-essing results in the development of smaller biologically active peptides that par-ticipate in the regulation of survival, proliferation and differentiation of cells, in different normal and pathologically changed tissues. The parathyroid hormone-related protein is produced by prostate cancer cells and many other tumors. The au-thors put their special attention to biochemical basis of mechanisms that cause ef-fects related to parathyroid hormone-related protein at patients with prostate can-cer. The survey covers the question of how the parathyroid hormone-related pro-tein participates in modulation of phenotypic developments of the onco-transformation if its tissue, as well as its role in formation of local and whole or-ganism reactions in response to the prostate cancer treatment. The main attention was devoted to the influence of the parathyroid hormone-related protein on the key effects in the development of cancer in natural conditions. The final remarks reflect the existing and potential possibilities to use the modern knowledge about the para-thyroid hormone-related protein in the clinical practice on the prostate cancer for the diagnostic purposes, as well as the targets for the anticancer therapy. The survey presents the data on the structure, biochemical characteristics and multifaceted role of this protein in the organism. The main part of the survey contains information about the different aspects of participation of the parathyroid hormone-related protein in development of the prostate cancer, in its metastasizing, the role in development of hormoneresistance, effect on apoptosis in prostate can-cer cells.

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