Translational Psychiatry (Jul 2022)
Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis
- Helen Baldwin,
- Joaquim Radua,
- Mathilde Antoniades,
- Shalaila S. Haas,
- Sophia Frangou,
- Ingrid Agartz,
- Paul Allen,
- Ole A. Andreassen,
- Kimberley Atkinson,
- Peter Bachman,
- Inmaculada Baeza,
- Cali F. Bartholomeusz,
- Michael W. L. Chee,
- Tiziano Colibazzi,
- Rebecca E. Cooper,
- Cheryl M. Corcoran,
- Vanessa L. Cropley,
- Bjørn H. Ebdrup,
- Adriana Fortea,
- Louise Birkedal Glenthøj,
- Holly K. Hamilton,
- Kristen M. Haut,
- Rebecca A. Hayes,
- Ying He,
- Karsten Heekeren,
- Michael Kaess,
- Kiyoto Kasai,
- Naoyuki Katagiri,
- Minah Kim,
- Jochen Kindler,
- Mallory J. Klaunig,
- Shinsuke Koike,
- Alex Koppel,
- Tina D. Kristensen,
- Yoo Bin Kwak,
- Jun Soo Kwon,
- Stephen M. Lawrie,
- Irina Lebedeva,
- Jimmy Lee,
- Ashleigh Lin,
- Rachel L. Loewy,
- Daniel H. Mathalon,
- Chantal Michel,
- Romina Mizrahi,
- Paul Møller,
- Barnaby Nelson,
- Takahiro Nemoto,
- Dorte Nordholm,
- Maria A. Omelchenko,
- Christos Pantelis,
- Jayachandra M. Raghava,
- Jan I. Røssberg,
- Wulf Rössler,
- Dean F. Salisbury,
- Daiki Sasabayashi,
- Ulrich Schall,
- Lukasz Smigielski,
- Gisela Sugranyes,
- Michio Suzuki,
- Tsutomu Takahashi,
- Christian K. Tamnes,
- Jinsong Tang,
- Anastasia Theodoridou,
- Sophia I. Thomopoulos,
- Alexander S. Tomyshev,
- Peter J. Uhlhaas,
- Tor G. Værnes,
- Therese A. M. J. van Amelsvoort,
- Theo G. M. Van Erp,
- James A. Waltz,
- Lars T. Westlye,
- Stephen J. Wood,
- Juan H. Zhou,
- Philip McGuire,
- Paul M. Thompson,
- Maria Jalbrzikowski,
- Dennis Hernaus,
- Paolo Fusar-Poli,
- the ENIGMA Clinical High Risk for Psychosis Working Group
Affiliations
- Helen Baldwin
- Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
- Joaquim Radua
- Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
- Mathilde Antoniades
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Shalaila S. Haas
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Sophia Frangou
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Ingrid Agartz
- Department of Psychiatric Research, Diakonhjemmet Hospital
- Paul Allen
- Department of Psychology, University of Roehampton
- Ole A. Andreassen
- KG Jebsen Center for Neurodevelopmental Disorders, University of Oslo
- Kimberley Atkinson
- Division of Psychiatry, University of Edinburgh
- Peter Bachman
- Department of Psychiatry, University of Pittsburgh
- Inmaculada Baeza
- Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, 2017SGR-881, Hospital Clinic Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Universitat de Barcelona
- Cali F. Bartholomeusz
- Centre for Youth Mental Health, University of Melbourne
- Michael W. L. Chee
- Center for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore
- Tiziano Colibazzi
- Department of Psychiatry, Columbia University
- Rebecca E. Cooper
- Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne & Melbourne Health
- Cheryl M. Corcoran
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Vanessa L. Cropley
- Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne & Melbourne Health
- Bjørn H. Ebdrup
- Centre for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, Copenhagen University Hospital
- Adriana Fortea
- Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic Barcelona, Fundació Clínic Recerca Biomèdica, Universitat de Barcelona
- Louise Birkedal Glenthøj
- Copenhagen Research Center for Mental Health, Mental Health Center Copenhagen, University of Copenhagen
- Holly K. Hamilton
- Department of Psychiatry and Behavioral Sciences, University of California San Francisco
- Kristen M. Haut
- Department of Psychiatry and Behavioral Sciences, Rush University Medical Center
- Rebecca A. Hayes
- Department of Psychiatry, University of Pittsburgh
- Ying He
- National Clinical Research Center for Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University
- Karsten Heekeren
- Department of Psychiatry and Psychotherapy I, LVR-Hospital Cologne
- Michael Kaess
- Department of Child and Adolescent Psychiatry, Center of Psychosocial Medicine, University of Heidelberg
- Kiyoto Kasai
- Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo
- Naoyuki Katagiri
- Department of Neuropsychiatry, Toho University School of Medicine
- Minah Kim
- Department of Neuropsychiatry, Seoul National University Hospital
- Jochen Kindler
- University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern
- Mallory J. Klaunig
- Department of Psychology, University of Maryland
- Shinsuke Koike
- The University of Tokyo Institute for Diversity and Adaptation of Human Mind
- Alex Koppel
- Department of Pharmacology and Toxicology, University of Toronto
- Tina D. Kristensen
- Centre for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, Copenhagen University Hospital
- Yoo Bin Kwak
- Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences
- Jun Soo Kwon
- Department of Neuropsychiatry, Seoul National University Hospital
- Stephen M. Lawrie
- Division of Psychiatry, University of Edinburgh
- Irina Lebedeva
- Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center
- Jimmy Lee
- Department of Psychosis, Institute of Mental Health
- Ashleigh Lin
- Telethon Kids Institute, The University of Western Australia
- Rachel L. Loewy
- Department of Psychiatry and Behavioral Sciences, University of California San Francisco
- Daniel H. Mathalon
- Department of Psychiatry and Behavioral Sciences, University of California San Francisco
- Chantal Michel
- University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern
- Romina Mizrahi
- Douglas Research Center
- Paul Møller
- Department for Mental Health Research and Development, Division of Mental Health and Addiction, Vestre Viken Hospital Trust
- Barnaby Nelson
- Centre for Youth Mental Health, University of Melbourne
- Takahiro Nemoto
- Department of Neuropsychiatry, Toho University School of Medicine
- Dorte Nordholm
- Copenhagen Research Center for Mental Health, Mental Health Center Copenhagen, University of Copenhagen
- Maria A. Omelchenko
- Department of Youth Psychiatry, Mental Health Research Center
- Christos Pantelis
- Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne & Melbourne Health
- Jayachandra M. Raghava
- Centre for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, Copenhagen University Hospital
- Jan I. Røssberg
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
- Wulf Rössler
- Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich
- Dean F. Salisbury
- Department of Psychiatry, University of Pittsburgh
- Daiki Sasabayashi
- Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences
- Ulrich Schall
- Priority Centre for Brain and Mental Health Research, The University of Newcastle
- Lukasz Smigielski
- Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich
- Gisela Sugranyes
- Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, 2017SGR-881, Hospital Clinic Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Universitat de Barcelona
- Michio Suzuki
- Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences
- Tsutomu Takahashi
- Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences
- Christian K. Tamnes
- Department of Psychiatric Research, Diakonhjemmet Hospital
- Jinsong Tang
- Department of Psychiatry, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
- Anastasia Theodoridou
- Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich
- Sophia I. Thomopoulos
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California
- Alexander S. Tomyshev
- Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center
- Peter J. Uhlhaas
- Institute of Neuroscience and Psychology, University of Glasgow
- Tor G. Værnes
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
- Therese A. M. J. van Amelsvoort
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health Medicine and Life Sciences, Maastricht University
- Theo G. M. Van Erp
- Center for the Neurobiology of Learning and Memory, University of California Irvine
- James A. Waltz
- Maryland Psychiatric Research Center, University of Maryland School of Medicine
- Lars T. Westlye
- KG Jebsen Center for Neurodevelopmental Disorders, University of Oslo
- Stephen J. Wood
- Centre for Youth Mental Health, University of Melbourne
- Juan H. Zhou
- Center for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore
- Philip McGuire
- Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Paul M. Thompson
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California
- Maria Jalbrzikowski
- Department of Psychiatry, University of Pittsburgh
- Dennis Hernaus
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health Medicine and Life Sciences, Maastricht University
- Paolo Fusar-Poli
- Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
- the ENIGMA Clinical High Risk for Psychosis Working Group
- DOI
- https://doi.org/10.1038/s41398-022-02057-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Abstract Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely undetermined. We aimed to quantify the neuroanatomical heterogeneity in structural magnetic resonance imaging measures of cortical surface area (SA), cortical thickness (CT), subcortical volume (SV), and intracranial volume (ICV) in CHR-P individuals compared with healthy controls (HC), and in relation to subsequent transition to a first episode of psychosis. The ENIGMA CHR-P consortium applied a harmonised analysis to neuroimaging data across 29 international sites, including 1579 CHR-P individuals and 1243 HC, offering the largest pooled CHR-P neuroimaging dataset to date. Regional heterogeneity was indexed with the Variability Ratio (VR) and Coefficient of Variation (CV) ratio applied at the group level. Personalised estimates of heterogeneity of SA, CT and SV brain profiles were indexed with the novel Person-Based Similarity Index (PBSI), with two complementary applications. First, to assess the extent of within-diagnosis similarity or divergence of neuroanatomical profiles between individuals. Second, using a normative modelling approach, to assess the ‘normativeness’ of neuroanatomical profiles in individuals at CHR-P. CHR-P individuals demonstrated no greater regional heterogeneity after applying FDR corrections. However, PBSI scores indicated significantly greater neuroanatomical divergence in global SA, CT and SV profiles in CHR-P individuals compared with HC. Normative PBSI analysis identified 11 CHR-P individuals (0.70%) with marked deviation (>1.5 SD) in SA, 118 (7.47%) in CT and 161 (10.20%) in SV. Psychosis transition was not significantly associated with any measure of heterogeneity. Overall, our examination of neuroanatomical heterogeneity within the CHR-P state indicated greater divergence in neuroanatomical profiles at an individual level, irrespective of psychosis conversion. Further large-scale investigations are required of those who demonstrate marked deviation.
