Molecules (Jul 2020)

New Terpendole Congeners, Inhibitors of Sterol <i>O</i>-Acyltransferase, Produced by <i>Volutella citrinella</i> BF-0440

  • Elyza Aiman Azizah Nur,
  • Keisuke Kobayashi,
  • Ai Amagai,
  • Taichi Ohshiro,
  • Hiroshi Tomoda

DOI
https://doi.org/10.3390/molecules25133079
Journal volume & issue
Vol. 25, no. 13
p. 3079

Abstract

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New terpendoles N-P (1–3) were isolated along with 8 structurally related known compounds including terpendoles and voluhemins from a culture broth of the fungus Volutella citrinella BF-0440. The structures of 1–3 were elucidated using various spectroscopic experiments including 1D- and 2D-NMR. All compounds 1–3 contained a common indole–diterpene backbone. Compounds 2 and 3 had 7 and 6 consecutive ring systems with an indole ring, respectively, whereas 1 had a unique indolinone plus 4 consecutive ring system. Compounds 2 and 3 inhibited both sterol O-acyltransferase 1 and 2 isozymes, but 1 lost the inhibitory activity. Structure–activity relationships of fungal indole–diterpene compounds are discussed.

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