R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

Teng Han; Emma M. Schatoff; Charles Murphy; Maria Paz Zafra; John E. Wilkinson; Olivier Elemento; Lukas E. Dow

doi:10.1038/ncomms15945

Nature Communications (Jul 2017)

R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

Teng Han,
Emma M. Schatoff,
Charles Murphy,
Maria Paz Zafra,
John E. Wilkinson,
Olivier Elemento,
Lukas E. Dow

Affiliations

Teng Han: Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine
Emma M. Schatoff: Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine
Charles Murphy: Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine
Maria Paz Zafra: Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine
John E. Wilkinson: Department of Pathology, University of Michigan School of Medicine
Olivier Elemento: Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine
Lukas E. Dow: Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine

DOI: https://doi.org/10.1038/ncomms15945
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Recent evidence suggests thatEIF3E–RSPO2 and PTPRK–RSPO3gene fusions promote colorectal cancer. Here, using CRISPR-mediated genome editing, the authors show that endogenous Rspo2 or Rspo3 chromosome rearrangements result in intestinal tumours extremely sensitive to Wnt ligand inhibition.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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