Drug Design, Development and Therapy (Aug 2022)
The Role of Histone H3 Methylation in Acute Kidney Injury
Abstract
Yi-Bo Zhao, Wei Wei, Xiao-Xi Lin, Yan-Fen Chai, Heng Jin Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, 300000, People’s Republic of ChinaCorrespondence: Heng Jin; Yan-Fen Chai, Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, 300000, People’s Republic of China, Email [email protected]; [email protected]: Acute kidney injury (AKI) is a clinical syndrome in which kidney function declines sharply due to various reasons. Although the morbidity and mortality of AKI are high, the mechanism of occurrence and development of AKI has not been fully elucidated, and precise prevention and treatment measures are lacking. Epigenetics is a branch of genetics that provides a new perspective to explore the pathophysiology of AKI and renal repair. A large amount of literature shows that the methylation mechanism of H3 in histones is closely related to the development of kidney diseases. The sorting out of histone H3 methylation mechanism in AKI and kidney repair can help understand the pathophysiological process of the disease more deeply. It may also provide new ideas for diagnosing and treating of the disease.Keywords: kidney, Acute kidney injury, histone methylation, epigenetic
