Nature Communications (Mar 2019)

The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression

  • Biao Ma,
  • Hongcheng Cheng,
  • Chenglong Mu,
  • Guangfeng Geng,
  • Tian Zhao,
  • Qian Luo,
  • Kaili Ma,
  • Rui Chang,
  • Qiangqiang Liu,
  • Ruize Gao,
  • Junli Nie,
  • Jiaying Xie,
  • Jinxue Han,
  • Linbo Chen,
  • Gui Ma,
  • Yushan Zhu,
  • Quan Chen

DOI
https://doi.org/10.1038/s41467-019-08618-y
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

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Tumor cell-microenvironment interactions generate heterogeneity and promote progression. Here, Ma et al. show that the E3 ligase SIAH2 degrades NRF1 in response to hypoxia to enhance pro-tumor metabolic and environmental effects, whereas NRF1 stabilization sensitizes tumor cells to apoptosis.