The diverse biological functions of glutathione S-transferase omega in Drosophila

Abstract

Glutathione S-transferase omega (GSTO) genes in eukaryotic organisms encode proteins that are important for cell defense. However, the physiological roles of GSTOs have not been fully elucidated yet. Recently, genetic and molecular studies with Drosophila demonstrated that CG6781 is the structural gene of the eye color mutant sepia and that CG6673 is a novel genetic suppressor of the parkin mutant. These results provide valuable insight into the diverse functions of GSTOs in vivo. In this review, we briefly introduce recent studies and summarize the novel biological functions of GSTOs in Drosophila.

Keywords

• ascorbic acid
• dehydroascorbate
• drosophila
• drosopterin
• eye pigments
• f1f0-atp synthase
• glutathione s-transferase omega
• pyrimidodiazepine