Эпилепсия и пароксизмальные состояния (May 2016)

ELECTROPHYSIOLOGICAL MECHANISMS OF ANTIEPILEPTIC ACTIONS REALIZATION OF BEPRODON

  • T. A. Voronina,
  • L. N. Nerobkova,
  • G. N. Avakyan,
  • A. V. Bakhutashvili,
  • G. G. Avakyan,
  • I. G. Kapitsa,
  • I. O. Gaidukov,
  • I. G. Kovalev

Journal volume & issue
Vol. 7, no. 1
pp. 8 – 19

Abstract

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The purpose of this research was to study electric and physiological mechanisms of the achievement of the antoconvulsant effect of the new original beprodon combination together with determination of determinant brain structures – therapeutic targets.Materials and Methods. Partial (focal) and secondary generalized convulsions were generated using the method of creation of a chronic epileptogenic focus, caused by the cobalt application on rats’ brain.Results: it was revealed, that at the first stage of the epileptic system (ES) beprodone is targeted to cortical focuses, and at the second stage – to subcortical focuses, generating epileptic activities. Conclusion: the beprodone effect depends on the stage of the epileptic system development and is targeted to determinant focuses.

Keywords