Effect of Foxtail Millet Intervention on Gut Microbiota in  High-fat-diet and STZ Induced Diabetic Rats

REN Xin; ZHANG Fu-long; QIN Meng-yuan; SHEN Qun

doi:10.16210/j.cnki.1007-7561.2022.04.011

Liang you shipin ke-ji (Jul 2022)

Effect of Foxtail Millet Intervention on Gut Microbiota in High-fat-diet and STZ Induced Diabetic Rats

REN Xin,
ZHANG Fu-long,
QIN Meng-yuan,
SHEN Qun

Affiliations

REN Xin: Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China；College of Food Science and Nutritional Engineering, National Center of Technology Innovation (Deep Processing of Highland Barley) in Food Industry, China Agricultural University, Beijing 100083, China
ZHANG Fu-long: Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China
QIN Meng-yuan: Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China
SHEN Qun: College of Food Science and Nutritional Engineering, National Center of Technology Innovation (Deep Processing of Highland Barley) in Food Industry, China Agricultural University, Beijing 100083, China

DOI: https://doi.org/10.16210/j.cnki.1007-7561.2022.04.011
Journal volume & issue: Vol. 30, no. 4
pp. 76 – 84

Abstract

Read online

Gut microbiota plays an important role in the occurrence and development of type 2 diabetes mellitus. In order to further explore the effect of foxtail millet on gut microbiota of diabetic rats, the 16S rRNA high throughput sequencing technology was used to compare the changes of gut microbial composition and relative abundance in the rats fed with high-fat diet combined with STZ, from two dimensions of horizontal (different groups) and vertical (before and after intervention), respectively. It was shown that foxtail millet can significantly increase the relative abundance of Ruminococcus_2 and Lactobacillus, and significantly reduce the relative abundance of Blautia. Foxtail millet intervention also decreased the ratio of Bacteroides to Firmicum in high-fat-diet and STZ induced diabetic rats. And these changes were related to physiological indexes. In conclusion, foxtail millet intervention can reverse the effect of type 2 diabetes on gut microbiota, and make the gut microbial composition of rats develop toward a more healthier direction.

Published in Liang you shipin ke-ji

ISSN: 1007-7561 (Print)
Publisher: Academy of National Food and Strategic Reserves Administration
Country of publisher: China
LCC subjects: Technology: Chemical technology: Food processing and manufacture; Technology: Home economics: Nutrition. Foods and food supply
Website: http://lyspkj.ijournal.cn/lyspkj/home

About the journal

Abstract

Keywords