Epigenetic alterations in cancer

Suganya Ilango; Biswaranjan Paital; Priyanka Jayachandran; Palghat Raghunathan Padma; Ramalingam Nirmaladevi

doi:10.2741/4847

Frontiers in Bioscience-Landmark (Mar 2020)

Epigenetic alterations in cancer

Suganya Ilango,
Biswaranjan Paital,
Priyanka Jayachandran,
Palghat Raghunathan Padma,
Ramalingam Nirmaladevi

Affiliations

Suganya Ilango: Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, 641043, Tamil Nadu, India
Biswaranjan Paital: Redox Regulation Laboratory, Department of Zoology, CBSH, Odisha University of Agriculture and Technology, Bhubaneswar-751003, India
Priyanka Jayachandran: Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, 641043, Tamil Nadu, India
Palghat Raghunathan Padma: Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, 641043, Tamil Nadu, India
Ramalingam Nirmaladevi: Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, 641043, Tamil Nadu, India

DOI: https://doi.org/10.2741/4847
Journal volume & issue: Vol. 25, no. 6
pp. 1058 – 1109

Abstract

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Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging and cancer. In human cancers, epigenetic changes such as DNA methylation, histone modifications, micro RNAs and nucleosome remodelling all control gene expression. The link between the genetics and epigenetics in cancer is further shown by existence of aberrant metabolism and biochemical pathways in cancer or mutation in genes that are epigenetic players. Reversal of these epigenetic changes has been clearly shown to have therapeutic value in various forms of lymphoma and preleukemia and similar results are appearing for the treatment of solid tumors. In this review, we discuss the functional effects of epigenetic changes inducible by hypoxia, the epigenetic alterations in cancer and how they contribute to tumor progression and their relevance to epigenetic therapy.

Published in Frontiers in Bioscience-Landmark

ISSN: 2768-6701 (Print); 2768-6698 (Online)
Publisher: IMR Press
Country of publisher: Singapore
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry; Science: Biology (General)
Website: https://www.imrpress.com/journal/FBL

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