Nature Communications (Nov 2019)
ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer
- Roxsan Manshouri,
- Etienne Coyaud,
- Samrat T. Kundu,
- David H. Peng,
- Sabrina A. Stratton,
- Kendra Alton,
- Rakhee Bajaj,
- Jared J. Fradette,
- Rosalba Minelli,
- Michael D. Peoples,
- Alessandro Carugo,
- Fengju Chen,
- Christopher Bristow,
- Jeffrey J. Kovacs,
- Michelle C. Barton,
- Tim Heffernan,
- Chad J. Creighton,
- Brian Raught,
- Don L. Gibbons
Affiliations
- Roxsan Manshouri
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Etienne Coyaud
- Department of Medical Biophysics, Princess Margaret Cancer Centre, University of Toronto
- Samrat T. Kundu
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- David H. Peng
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Sabrina A. Stratton
- Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
- Kendra Alton
- Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
- Rakhee Bajaj
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Jared J. Fradette
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Rosalba Minelli
- Department of Cancer Genomics, The University of Texas MD Anderson Cancer Center
- Michael D. Peoples
- Department of Cancer Genomics, The University of Texas MD Anderson Cancer Center
- Alessandro Carugo
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Fengju Chen
- Department of Medicine and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Christopher Bristow
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Jeffrey J. Kovacs
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Michelle C. Barton
- Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
- Tim Heffernan
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Chad J. Creighton
- Department of Medicine and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Brian Raught
- Department of Medical Biophysics, Princess Margaret Cancer Centre, University of Toronto
- Don L. Gibbons
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-019-12832-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Non-small cell lung cancer (NSCLC) is often associated with metastasis to the lungs. Here, the authors perform independent screens and identify NuRD as a co-repressor of ZEB1, and demonstrate TBC1D2b as a downstream target of ZEB1/NuRD complex regulating NSCLC metastasis.
