Molecules (Nov 2018)

Synthesis and Biological Evaluation of Phaeosphaeride A Derivatives as Antitumor Agents

  • Victoria Abzianidze,
  • Petr Beltyukov,
  • Sofya Zakharenkova,
  • Natalia Moiseeva,
  • Jennifer Mejia,
  • Alvin Holder,
  • Yuri Trishin,
  • Alexander Berestetskiy,
  • Victor Kuznetsov

DOI
https://doi.org/10.3390/molecules23113043
Journal volume & issue
Vol. 23, no. 11
p. 3043

Abstract

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New derivatives of phaeosphaeride A (PPA) were synthesized and characterized. Anti-tumor activity studies were carried out on the HCT-116, PC3, MCF-7, A549, К562, NCI-Н929, Jurkat, THP-1, RPMI8228 tumor cell lines, and on the HEF cell line. All of the compounds synthesized were found to have better efficacy than PPA towards the tumor cell lines mentioned. Compound 6 was potent against six cancer cell lines, HCT-116, PC-3, K562, NCI-H929, Jurkat, and RPMI8226, showing a 47, 13.5, 16, 4, 1.5, and 7-fold increase in anticancer activity comparative to those of etoposide, respectively. Compound 1 possessed selectivity toward the NCI-H929 cell line (IC50 = 1.35 ± 0.69 μM), while product 7 was selective against three cancer cell lines, HCT-116, MCF-7, and NCI-H929, each having IC50 values of 1.65 μM, 1.80 μM and 2.00 μM, respectively.

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