Nature Communications (May 2022)

Alternative splicing modulation by G-quadruplexes

  • Ilias Georgakopoulos-Soares,
  • Guillermo E. Parada,
  • Hei Yuen Wong,
  • Ragini Medhi,
  • Giulia Furlan,
  • Roberto Munita,
  • Eric A. Miska,
  • Chun Kit Kwok,
  • Martin Hemberg

DOI
https://doi.org/10.1038/s41467-022-30071-7
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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Here the authors shows that G-quadruplexes, non-canonical DNA/RNA structures, can have a direct impact on alternative splicing and that binding of splicing regulators is affected by their presence.