The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo; Zuni I. Bassi; Marco Geymonat; Sofia Todesca; Liviu Copoiu; Anton J. Enright; Giuliano Callaini; Maria Giovanna Riparbelli; Lu Yu; Jyoti S. Choudhary; Enrico Ferrero; Sally Wheatley; Max E. Douglas; Masanori Mishima; Pier Paolo D’Avino

doi:10.1038/s41467-019-12507-9

Nature Communications (Oct 2019)

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo,
Zuni I. Bassi,
Marco Geymonat,
Sofia Todesca,
Liviu Copoiu,
Anton J. Enright,
Giuliano Callaini,
Maria Giovanna Riparbelli,
Lu Yu,
Jyoti S. Choudhary,
Enrico Ferrero,
Sally Wheatley,
Max E. Douglas,
Masanori Mishima,
Pier Paolo D’Avino

Affiliations

Luisa Capalbo: Department of Pathology, University of Cambridge
Zuni I. Bassi: Department of Pathology, University of Cambridge
Marco Geymonat: Department of Genetics, University of Cambridge
Sofia Todesca: Department of Pathology, University of Cambridge
Liviu Copoiu: Department of Pathology, University of Cambridge
Anton J. Enright: Department of Pathology, University of Cambridge
Giuliano Callaini: Department of Medical Biotechnologies, University of Siena
Maria Giovanna Riparbelli: Department of Life Sciences, University of Siena
Lu Yu: The Wellcome Trust Sanger Institute, Wellcome Genome Campus
Jyoti S. Choudhary: The Wellcome Trust Sanger Institute, Wellcome Genome Campus
Enrico Ferrero: Department of Genetics, University of Cambridge
Sally Wheatley: School of Life Sciences, University of Nottingham
Max E. Douglas: Wellcome Trust/Cancer Research UK Gurdon Institute
Masanori Mishima: Wellcome Trust/Cancer Research UK Gurdon Institute
Pier Paolo D’Avino: Department of Pathology, University of Cambridge

DOI: https://doi.org/10.1038/s41467-019-12507-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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The midbody is an organelle present at the bridge connecting two cells at the end of cell division. Here, the authors use mass spectrometry to define the midbody interactome and uncover a role for PP1 phosphatases in microtubule dynamics and regulation of cytokinesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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