Dose-Response (Oct 2014)

Show a Threshold Effect in Response to Radiation

  • Michael Antosh,
  • David Fox,
  • Thomas Hasselbacher,
  • Robert Lanou,
  • Nicola Neretti,
  • Leon N. Cooper

DOI
https://doi.org/10.2203/dose-response.13-047.Antosh
Journal volume & issue
Vol. 12

Abstract

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We investigate the biological effects of radiation using adult Drosophila melanogaster as a model organism, focusing on gene expression and lifespan analysis to determine the effect of different radiation doses. Our results support a threshold effect in response to radiation: no effect on lifespan and no permanent effect on gene expression is seen at incident radiation levels below 100 J/kg. We also find that it is more appropriate to compare radiation effects in flies using the absorbed energy rather than incident radiation levels.