The antioxidant activity of propofol in chicks

Abstract

The aim of this study was to detect the antioxidant effects of propofol in chicks by estimation of glutathione concentrationin blood plasma, brain and liver as well as total antioxidant capacity and antioxidant effects of propofol in vitro by usinghydrogen peroxide as oxidative stress. Propofol at 20 mg/kg, intraperitoneally significantly increased after 4 hours theconcentration of glutathione concentration in plasma and brain compared with the control group and with 5 and 10mg propofolgroups. Propofol at 5, 10 and 20 mg/kg, i.p significantly increased glutathione concentration in the liver compared with thecontrol group. Propofol at 5, 10 and 20 mg/kg, i.p increased the efflux rate constant by 882, 1031 and 920 %, increasedglutathione turnover rate by 880, 1028, and 917 % and decreased the turnover time by 89, 91 and 90% in the liver. In the brainpropofol at 5, 10 and 20 mg/kg, i.p increased efflux rate constant as 26, 600 and 2826 % and increased glutathione turnoverrate by 29, 616 and 2894 % and a decreased in the turnover time by 21, 86 and 96%. Propofol at 10 and 20 mg/kg, i.psignificantly increased after 20 hours the TAC in the serum of the chick by 38 and 48%, respectively compared with thecontrol group. Propofol at concentrations of 25, 50 and 100 micromoles / liter decreased erythrocyte hemolysis induced byhydrogen peroxide in vitro 10 micromoles / liter in a concentration depended manner by 25, 49 and 64 % respectively. In conclusion, Propofol have antioxidant effect in vivo and in vitro in the chicks. Propofol have a protection against oxidativestress.

Keywords

• antioxidant activity
• propofol
• chicks