Discussion of astrocytic mitochondria as a therapeutic target for ischemic stroke

Abstract

Ischemic stroke is a common acute cerebrovascular disease in the middle-aged and elderly,and one of the most fatal diseases in the world.There are limited treatment options that currently exist and only apply to a small proportion of stroke patients,so developing effective treatments to reduce brain damage is critical.Astrocytes are the core components of the central nervous system.Mitochondrial dysfunction is the initial event of ischemic stroke and plays an important role in neuronal survival and neurological function improvement.In this paper,based on the role of astrocytic mitochondria in the pathogenesis of ischemic stroke,the changes of the biological energy and dynamics of astrocytic mitochondria,the functional transfer to neurons and the regulation of astrocytic mitochondria on cerebral blood flow by astrocytic mitochondrice were discussed.Emphasized that astrocytic mitochondria can be used as one of the targets for the treatment of ischemic stroke,so as to better understand the role of astrocytic mitochondria in the process of ischemia-induced neuronal death,and to provide a theoretical basis for the new treatment of ischemic stroke.

Keywords

• neurobiochemistry; astrocyte; mitochondria; ischemic stroke; brain damage