PLoS ONE (Jan 2015)

Antiretroviral Drug Use in a Cohort of HIV-Uninfected Women in the United States: HIV Prevention Trials Network 064.

  • Iris Chen,
  • William Clarke,
  • San-San Ou,
  • Mark A Marzinke,
  • Autumn Breaud,
  • Lynda M Emel,
  • Jing Wang,
  • James P Hughes,
  • Paul Richardson,
  • Danielle F Haley,
  • Jonathan Lucas,
  • Anne Rompalo,
  • Jessica E Justman,
  • Sally L Hodder,
  • Susan H Eshleman

DOI
https://doi.org/10.1371/journal.pone.0140074
Journal volume & issue
Vol. 10, no. 10
p. e0140074

Abstract

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Antiretroviral (ARV) drug use was analyzed in HIV-uninfected women in an observational cohort study conducted in 10 urban and periurban communities in the United States with high rates of poverty and HIV infection. Plasma samples collected in 2009-2010 were tested for the presence of 16 ARV drugs. ARV drugs were detected in samples from 39 (2%) of 1,806 participants: 27/181 (15%) in Baltimore, MD and 12/179 (7%) in Bronx, NY. The ARV drugs detected included different combinations of non-nucleoside reverse transcriptase inhibitors and protease inhibitors (1-4 drugs/sample). These data were analyzed in the context of self-reported data on ARV drug use. None of the 39 women who had ARV drugs detected reported ARV drug use at any study visit. Further research is needed to evaluate ARV drug use by HIV-uninfected individuals.