Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation

Matouš Vobořil; Tomáš Brabec; Jan Dobeš; Iva Šplíchalová; Jiří Březina; Adéla Čepková; Martina Dobešová; Aigerim Aidarova; Jan Kubovčiak; Oksana Tsyklauri; Ondřej Štěpánek; Vladimír Beneš; Radislav Sedláček; Ludger Klein; Michal Kolář; Dominik Filipp

doi:10.1038/s41467-020-16081-3

Nature Communications (May 2020)

Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation

Matouš Vobořil,
Tomáš Brabec,
Jan Dobeš,
Iva Šplíchalová,
Jiří Březina,
Adéla Čepková,
Martina Dobešová,
Aigerim Aidarova,
Jan Kubovčiak,
Oksana Tsyklauri,
Ondřej Štěpánek,
Vladimír Beneš,
Radislav Sedláček,
Ludger Klein,
Michal Kolář,
Dominik Filipp

Affiliations

Matouš Vobořil: Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences
Tomáš Brabec: Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences
Jan Dobeš: Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences
Iva Šplíchalová: Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences
Jiří Březina: Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences
Adéla Čepková: Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences
Martina Dobešová: Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences
Aigerim Aidarova: Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences
Jan Kubovčiak: Laboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences
Oksana Tsyklauri: Laboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences
Ondřej Štěpánek: Laboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences
Vladimír Beneš: Genomics Core Facility, EMBL, Services & Technology Unit
Radislav Sedláček: Czech Centre for Phenogenomics & Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the Czech Academy of Sciences
Ludger Klein: Faculty of Medicine, Institute for Immunology, Ludwig-Maximilans-Universitat
Michal Kolář: Laboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences
Dominik Filipp: Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences

DOI: https://doi.org/10.1038/s41467-020-16081-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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Immune tolerance is mediated by the deletion of autoreactive T cells via medullary thymic epithelial cells (mTEC) and dendritic cells (DC), and by the induction of regulatory T cells (Treg). Here the authors show that mTEC receiving toll-like receptor signaling control the recruitment of CD14+Sirpα+ DC population that is capable of inducing Treg for establishing tolerance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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