Nature Communications (Nov 2020)
Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis
- Lúcia Moreira-Teixeira,
- Philippa J. Stimpson,
- Evangelos Stavropoulos,
- Sabelo Hadebe,
- Probir Chakravarty,
- Marianna Ioannou,
- Iker Valle Aramburu,
- Eleanor Herbert,
- Simon L. Priestnall,
- Alejandro Suarez-Bonnet,
- Jeremy Sousa,
- Kaori L. Fonseca,
- Qian Wang,
- Sergo Vashakidze,
- Paula Rodríguez-Martínez,
- Cristina Vilaplana,
- Margarida Saraiva,
- Venizelos Papayannopoulos,
- Anne O’Garra
Affiliations
- Lúcia Moreira-Teixeira
- Laboratory of Immunoregulation and Infection, The Francis Crick Institute
- Philippa J. Stimpson
- Laboratory of Immunoregulation and Infection, The Francis Crick Institute
- Evangelos Stavropoulos
- Laboratory of Immunoregulation and Infection, The Francis Crick Institute
- Sabelo Hadebe
- Laboratory of Immunoregulation and Infection, The Francis Crick Institute
- Probir Chakravarty
- Bioinformatics and Biostatistics Team, The Francis Crick Institute
- Marianna Ioannou
- Laboratory of Antimicrobial Defence, The Francis Crick Institute
- Iker Valle Aramburu
- Laboratory of Antimicrobial Defence, The Francis Crick Institute
- Eleanor Herbert
- Department of Pathobiology and Population Sciences, Royal Veterinary College
- Simon L. Priestnall
- Department of Pathobiology and Population Sciences, Royal Veterinary College
- Alejandro Suarez-Bonnet
- Department of Pathobiology and Population Sciences, Royal Veterinary College
- Jeremy Sousa
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
- Kaori L. Fonseca
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
- Qian Wang
- Laboratory of Antimicrobial Defence, The Francis Crick Institute
- Sergo Vashakidze
- National Center for Tuberculosis and Lung Diseases (NCTLD)
- Paula Rodríguez-Martínez
- Pathology Department, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona (UAB)
- Cristina Vilaplana
- Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona (UAB), CIBER Enfermedades Respiratorias. Edifici Laboratoris de Recerca. Can Ruti Campus
- Margarida Saraiva
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
- Venizelos Papayannopoulos
- Laboratory of Antimicrobial Defence, The Francis Crick Institute
- Anne O’Garra
- Laboratory of Immunoregulation and Infection, The Francis Crick Institute
- DOI
- https://doi.org/10.1038/s41467-020-19412-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
GM-CSF is involved in control over M. tuberculosis infection. Here the authors show that GM-CSF reduces type 1 interferon driven neutrophil recruitment, NETosis and bacterial growth in the lungs of infected mice, and provide evidence that this NETosis occurs in infected humans who are not responsive to antibiotic therapy.
