West Nile Virus Infection in Plasma of Blood and Plasma Donors, United States

Abstract

This study investigated the association of ongoing West Nile virus (WNV) infections with neutralizing antibody titers in US plasma-derived intravenous immune globulin released during 2003–2008. Titers correlated closely with the prevalence of past WNV infection in blood donors, with 2008 lots indicating a prevalence of 1%.

Keywords

• West Nile virus
• intravenous immunoglobulins
• IGIV
• viral antibodies
• neutralization tests
• epidemiology