Nature Communications (Feb 2018)

Two distinct domains contribute to the substrate acyl chain length selectivity of plant acyl-ACP thioesterase

  • Fuyuan Jing,
  • Le Zhao,
  • Marna D. Yandeau-Nelson,
  • Basil J. Nikolau

DOI
https://doi.org/10.1038/s41467-018-03310-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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The substrate specificity of acyl-ACP thioesterase (TE) plays a crucial role in determining the product profile of type II fatty acid synthase. Utilizing two FatB-type acyl-ACP TEs, the authors here define determinants of substrate specificity and create synthetic enzymes with distinct catalytic traits.