The Role of Selective Serotonin Reuptake Inhibitors in Premature Ejaculation

Abstract

Premature ejaculation is a very common male sexual medical illness worldwide. Amongst several biological risk factors, the disturbance of central serotonin neurotransmission is one important cause. Various research has allowed a better understanding of the development of this disorder, as well as allowing for improved treatment options in order to decrease the significant morbidity associated with this condition; among the more recent treatments, selective serotonin reuptake inhibitors are believed to be one of the best. During this review, the action and role of serotonin reuptake inhibitors at different levels will be discussed, along with their relevance and effectiveness in the treatment of premature ejaculation.

Keywords

• dapoxetine
• fluoxetine
• premature ejaculation (pe)
• selective serotonin reuptake inhibitors (ssri)
• serotonin
• 5-ht receptors