Nature Communications (Aug 2021)
The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue
- Bo Wang,
- Evangelia E. Tsakiridis,
- Shuman Zhang,
- Andrea Llanos,
- Eric M. Desjardins,
- Julian M. Yabut,
- Alexander E. Green,
- Emily A. Day,
- Brennan K. Smith,
- James S. V. Lally,
- Jianhan Wu,
- Amogelang R. Raphenya,
- Krishna A. Srinivasan,
- Andrew G. McArthur,
- Shingo Kajimura,
- Jagdish Suresh Patel,
- Michael G. Wade,
- Katherine M. Morrison,
- Alison C. Holloway,
- Gregory R. Steinberg
Affiliations
- Bo Wang
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- Evangelia E. Tsakiridis
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- Shuman Zhang
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- Andrea Llanos
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- Eric M. Desjardins
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- Julian M. Yabut
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- Alexander E. Green
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- Emily A. Day
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- Brennan K. Smith
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- James S. V. Lally
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- Jianhan Wu
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- Amogelang R. Raphenya
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- Krishna A. Srinivasan
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- Andrew G. McArthur
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- Shingo Kajimura
- Beth Israel Deaconess Medical Center and Harvard Medical School
- Jagdish Suresh Patel
- Institute for Modeling Collaboration and Innovation, University of Idaho
- Michael G. Wade
- Environmental Health Science & Research Bureau, Health Canada
- Katherine M. Morrison
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- Alison C. Holloway
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- Gregory R. Steinberg
- Centre for Metabolism, Obesity and Diabetes Research, McMaster University
- DOI
- https://doi.org/10.1038/s41467-021-25384-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Chlorpyrifos is a widely-used pesticide and a common residue on vegetables and fruits. Here the authors show that at non-neurotoxic doses, chlorpyrifos reduces energy expenditure, by inhibiting diet induced thermogenesis, and promotes obesity and insulin resistance.
