High Seropositivity Rate of Neutralizing Antibodies to Astrovirus VA1 in Human Populations

Andrew B. Janowski; Macee C. Owen; Holly Dudley; Tomás López; Rafaela Espinosa; Memory Elvin-Lewis; Alejandro Colichon; Carlos F. Arias; Peter D. Burbelo; David Wang

doi:10.1128/mSphere.00484-21

mSphere (Oct 2021)

High Seropositivity Rate of Neutralizing Antibodies to Astrovirus VA1 in Human Populations

Andrew B. Janowski,
Macee C. Owen,
Holly Dudley,
Tomás López,
Rafaela Espinosa,
Memory Elvin-Lewis,
Alejandro Colichon,
Carlos F. Arias,
Peter D. Burbelo,
David Wang

Affiliations

Andrew B. Janowski: ORCiD; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA
Macee C. Owen: Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA
Holly Dudley: Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA
Tomás López: Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico
Rafaela Espinosa: Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico
Memory Elvin-Lewis: Department of Biology, Washington University, St. Louis, Missouri, USA
Alejandro Colichon: Department of Immunology, Peruvian University Cayetano Heredia, Lima, Peru
Carlos F. Arias: ORCiD; Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico
Peter D. Burbelo: National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
David Wang: ORCiD; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

DOI: https://doi.org/10.1128/mSphere.00484-21
Journal volume & issue: Vol. 6, no. 5

Abstract

Read online

Astroviruses are human pathogens with emerging disease associations, including the recent recognition of their capacity to cause meningoencephalitis. Astrovirus VA1 is the most commonly identified astrovirus genotype from cases of human encephalitis, but it is unknown what percentage of the human population has neutralizing antibodies to VA1.

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

About the journal