Molbank (Dec 2022)

4-Methoxyphenethyl (<i>E</i>)-3-(<i>o</i>-tolyl)acrylate

  • Mardi Santoso,
  • Egar Pamela,
  • Ersya Yanu Ramadhani,
  • Yan Alamanda Ilfahmi,
  • Nur Pasca Aijijiyah,
  • Adi Setyo Purnomo,
  • Surya Rosa Putra

DOI
https://doi.org/10.3390/M1519
Journal volume & issue
Vol. 2022, no. 4
p. M1519

Abstract

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4-Methoxyphenethyl (E)-3-(o-tolyl)acrylate (1) was obtained in a good yield by the reaction of 2-methylcinnamic acid, 4-methoxyphenethyl alcohol, 2-methyl-6-nitrobenzoic anhydride, 4-dimethylaminopyridine, and triethylamine at room temperature for 40 min. The structure of 4-methoxyphenethyl (E)-3-(o-tolyl)acrylate (1) was established by FTIR, NMR, and the high resolution of mass spectroscopies. 4-Methoxyphenethyl (E)-3-(o-tolyl)acrylate (1) showed higher α-glucosidase inhibition activity than standard drug acarbose. The molecular docking study exhibited that the title compound 1 had a good affinity for α-glucosidase (PDB ID: 3W37) and formed some interactions with the α-glucosidase active site residue.

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