OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR

Xuhong Fu; Junjie Zhao; Guopeng Yu; Xiaomin Zhang; Jie Sun; Lingmeng Li; Jingyi Yin; Yinan Niu; Shancheng Ren; Yasheng Zhu; Bin Xu; Liyu Huang

doi:10.1038/s42003-022-03133-1

Communications Biology (Mar 2022)

OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR

Xuhong Fu,
Junjie Zhao,
Guopeng Yu,
Xiaomin Zhang,
Jie Sun,
Lingmeng Li,
Jingyi Yin,
Yinan Niu,
Shancheng Ren,
Yasheng Zhu,
Bin Xu,
Liyu Huang

Affiliations

Xuhong Fu: Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
Junjie Zhao: Department of General Surgery, Zhongshan Hospital, General Surgery Research Institute, Fudan University
Guopeng Yu: Department of Urology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Xiaomin Zhang: Department of Urology, Shanghai Changhai Hospital
Jie Sun: Department of General Surgery, Zhongshan Hospital, General Surgery Research Institute, Fudan University
Lingmeng Li: Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
Jingyi Yin: Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
Yinan Niu: Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
Shancheng Ren: Department of Urology, Shanghai Changhai Hospital
Yasheng Zhu: Department of Urology, Shanghai Changhai Hospital
Bin Xu: Department of Urology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Liyu Huang: Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University

DOI: https://doi.org/10.1038/s42003-022-03133-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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OTUD6A, a deubiquitinase, is amplified in prostate cancer and correlates with poor survivability, increasing the growth of prostate cancer cell lines and PDX models. OTUD6A stabilizes the expression of Brg1 and AR through the removal of K27- and K11-linked polyubiquination.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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