The role of cognitive reserve and clinical symptoms in the association between genetic liability for educational attainment and functioning in first-episode psychosis: a mediation analysis

• Derek Clougher,
• Àlex G Segura,
• Maria Florencia Forte,
• Gisela Mezquida,
• Manuel J Cuesta,
• Eduard Vieta,
• Silvia Amoretti,
• Antonio Lobo,
• Ana González-Pinto,
• Covadonga M. Díaz-Caneja,
• Alexandra Roldán,
• Giovanna Fico,
• Elena de la Serna,
• Daniel Bergé,
• Patricia Gassó,
• Natalia Rodriguez,
• Norma Verdolini,
• Alfonso Tortorella,
• Giulia Menculini,
• Marta Ribasés,
• Miguel Bernardo,
• Sergi Mas,
• PEPs Group

Affiliations

Derek Clougher

ORCiD

Bipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain. Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.

Àlex G Segura

ORCiD

Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain.

Maria Florencia Forte

ORCiD

Bipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain. Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Barcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute, University of Barcelona, August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Spain.

Gisela Mezquida

ORCiD

Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain. Barcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute, University of Barcelona, August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Spain.

Manuel J Cuesta

ORCiD

Department of Psychiatry, Complejo Hospitalario de Navarra, Pamplona, Spain. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.

Eduard Vieta

ORCiD

Bipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain. Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.

Silvia Amoretti

ORCiD

Bipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain. Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Barcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute, University of Barcelona, August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Spain. Group of Psychiatry, Mental Health and Addictions, Vall d’Hebron Research Institute (VHIR), Psychiatric Genetics Unit, Vall d’Hebron Research Institute (VHIR), Barcelona, Catalonia, Spain.

Antonio Lobo

ORCiD

Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Medicine and Psychiatry. Zaragoza University. Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain.

Ana González-Pinto

Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Araba University Hospital, Bioaraba Research Institute, Spain. University of the Basque Country (UPV-EHU), Spain.

Covadonga M. Díaz-Caneja

ORCiD

Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, IiSGM, Madrid, Spain.

Alexandra Roldán

Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Psychiatry, Institut d’Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.

Giovanna Fico

ORCiD

Bipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain. Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.

Elena de la Serna

ORCiD

Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Child and Adolescent Psychiatry and Psychology, 2017SGR881, Institut Clinic de Neurociències, Hospital Clínic Universitari, IDIBAPS, Department of Medicine, University of Barcelona, Barcelona, Spain.

Daniel Bergé

ORCiD

Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Hospital del Mar Medical Research Institute; Universitat Pompeu Fabra, MELIS Department, Barcelona, Spain.

Patricia Gassó

ORCiD

Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain.

Natalia Rodriguez

ORCiD

Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain.

Norma Verdolini

ORCiD

Local Health Unit Umbria 1, Department of Mental Health, Mental Health Center of Perugia, Italy.

Alfonso Tortorella

ORCiD

Section of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Giulia Menculini

ORCiD

Section of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Marta Ribasés

Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Group of Psychiatry, Mental Health and Addictions, Vall d’Hebron Research Institute (VHIR), Psychiatric Genetics Unit, Vall d’Hebron Research Institute (VHIR), Barcelona, Catalonia, Spain.

Miguel Bernardo

ORCiD

Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Barcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute, University of Barcelona, August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Spain.

Sergi Mas

ORCiD

Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain.

PEPs Group