An Efficient Synthesis of Acenaphtho[1,2-<i>b</i>]indole Derivatives via Domino Reaction

Guo-Ning Zhang; Xia Yuan; Weiping Niu; Mei Zhu; Juxian Wang; Yucheng Wang

doi:10.3390/molecules23113045

Molecules (Nov 2018)

An Efficient Synthesis of Acenaphtho[1,2-<i>b</i>]indole Derivatives via Domino Reaction

Guo-Ning Zhang,
Xia Yuan,
Weiping Niu,
Mei Zhu,
Juxian Wang,
Yucheng Wang

Affiliations

Guo-Ning Zhang: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China
Xia Yuan: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
Weiping Niu: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China
Mei Zhu: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China
Juxian Wang: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China
Yucheng Wang: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China

DOI: https://doi.org/10.3390/molecules23113045
Journal volume & issue: Vol. 23, no. 11
p. 3045

Abstract

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A concise and efficient synthesis of acenaphtho[1,2-b]indole derivatives via the domino reactions of enaminones with acenaphthoquinone catalyzed by l-proline has been developed. This protocol has the advantages of good yields, operational convenience and high regioselectivity.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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Abstract

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