PLoS ONE (Jan 2020)

Analysis of depressive episodes, their recurrence and pharmacologic treatment in primary care patients: A retrospective descriptive study.

  • Shysset Nuggerud-Galeas,
  • Loreto Sáez-Benito Suescun,
  • Nuria Berenguer Torrijo,
  • Ana Sáez-Benito Suescun,
  • Alejandra Aguilar-Latorre,
  • Rosa Magallón Botaya,
  • Bárbara Oliván Blázquez

DOI
https://doi.org/10.1371/journal.pone.0233454
Journal volume & issue
Vol. 15, no. 5
p. e0233454

Abstract

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BACKGROUND:Depression is one of the most prevalent health problems, frequently being a medium- and long-term condition, with a high comorbidity rate and with frequent relapses and recurrences. Although numerous studies have compared the effectiveness of specific antidepressant therapy drugs and have assessed relapses, scientific evidence on the relationship between pharmacologic treatments and recurrence is scarce. The objective of this study is to describe depressive episodes in a primary care patient cohort, the percentage of depression recurrences and the administered pharmacologic treatment, from a naturalistic perspective. METHODS:Retrospective descriptive study. 957 subjects were included. The dependent variable was a depression diagnosis and independent variables were: gender, age at time of data collection; age of onset, first-episode treatment, number of recurrences, age at recurrences, treatment prescribed for recurrences using therapeutic groups categorization. RESULTS:Recurrences are frequent, affecting more than 40% of the population. In the first episode, 13.69% of the patients were not prescribed pharmacological treatment, but this percentage decreased over the following depression episodes. 80.9% of the patients who did not receive drug treatment in the first depression episode did not experience subsequent episodes. Monotherapy, and specifically, SSRIs were the most frequently prescribed treatment option for all depressive episodes. Regards the combined pharmacologic treatment, the most frequent drug combinations were SSRIs and benzodiazepines. LIMITATIONS:In order to increase the power of results, the statistical analysis was performed using therapeutic groups categorization, not individually analyzing each drug and dose. CONCLUSIONS:Depressive episode recurrence is frequent in primary care patients. Further studies having a prospective design are needed in order to expand on this issue.