Quality of glycemic control in type 2 diabetes mellitus (T2DM) and its association with markers of coagulation and inhibitors of fibrinolysis: A case–control study in the Upper West Region, Ghana

Peter K. Selleh; Enoch O. Anto; Wina I. O. Boadu; Benedict Sackey; Lilian A. Boateng; Charles Nkansah; Frederick Nsafoah; Abdul R. Saasi; Selina Mintaah; Yaw A. Wiafe; Charles Derigubah; Emmanuel E. Korsah; Joseph Frimpong; Ezekiel Ansah; Valentine C. K. T. Tamakloe; Patrick Adu; Joseph Boachie; Otchere Addai‐Mensah

doi:10.1002/hsr2.1297

Health Science Reports (Jun 2023)

Quality of glycemic control in type 2 diabetes mellitus (T2DM) and its association with markers of coagulation and inhibitors of fibrinolysis: A case–control study in the Upper West Region, Ghana

Peter K. Selleh,
Enoch O. Anto,
Wina I. O. Boadu,
Benedict Sackey,
Lilian A. Boateng,
Charles Nkansah,
Frederick Nsafoah,
Abdul R. Saasi,
Selina Mintaah,
Yaw A. Wiafe,
Charles Derigubah,
Emmanuel E. Korsah,
Joseph Frimpong,
Ezekiel Ansah,
Valentine C. K. T. Tamakloe,
Patrick Adu,
Joseph Boachie,
Otchere Addai‐Mensah

Affiliations

Peter K. Selleh: Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana
Enoch O. Anto: Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana
Wina I. O. Boadu: Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana
Benedict Sackey: Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana
Lilian A. Boateng: Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana
Charles Nkansah: Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana
Frederick Nsafoah: Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana
Abdul R. Saasi: Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana
Selina Mintaah: Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana
Yaw A. Wiafe: Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana
Charles Derigubah: Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana
Emmanuel E. Korsah: Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana
Joseph Frimpong: Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana
Ezekiel Ansah: Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana
Valentine C. K. T. Tamakloe: Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana
Patrick Adu: Department of Medical Laboratory Science, School of Allied Health Sciences University of Cape Coast Cape Coast Ghana
Joseph Boachie: Department of Medical Laboratory Science, School of Allied Health Sciences University of Cape Coast Cape Coast Ghana
Otchere Addai‐Mensah: Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana

DOI: https://doi.org/10.1002/hsr2.1297
Journal volume & issue: Vol. 6, no. 6
pp. n/a – n/a

Abstract

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Abstract Background and Aims Type 2 diabetes mellitus (T2DM) individuals are at a higher risk of developing diabetes complications, with approximately 80% complication‐related mortality. The increased morbidity and mortality among T2DM patients are partly due to dysregulated hemostasis. This study determined the quality of glycemic control in T2DM and its association with markers of coagulation and inhibitors of fibrinolysis. Methods This case–control study recruited 90 participants involving: 30 T2DM patients with good glycemic control, 30 with poor glycemic control, and 30 nondiabetic subjects as controls at a Municipal Hospital in Ghana. Fasting blood glucose, glycated hemoglobin, activated partial thromboplastin time (APTT), prothrombin time (PT), calculated international normalized ratio (INR), and full blood count (FBC) were determined for each respondent. Plasma levels of plasminogen activator inhibitor‐1 (PAI‐1) and thrombin activatable fibrinolysis inhibitor (TAFI) were determined using the solid‐phase sandwich enzyme‐linked immunosorbent assay method. Data were analyzed using R language software. Results Plasma PAI‐1 antigen levels were significantly higher in the participants with poor glycemic control as compared to participants with good glycemic control (p < 0.0001). There was no significant difference in plasma TAFI levels between the participants with poor glycemic control as compared to participants with good glycemic control (p = 0.900). T2DM patients had significantly shorter APTT, PT, and INR than controls (p < 0.05). At a cut‐off of ≥161.70 pg/μL, PAI was independently associated with increasing odds (adjusted odds ratio = 13.71, 95% confidence interval: 3.67–51.26, p < 0.0001) of poor glycemic control and showed the best diagnostic accuracy for poor glycemic control (area under the curve = 0.85, p < 0.0001). Conclusion PAI‐1 levels were significantly increased in T2DM with poor glycemic control and emerged as the best predictor for poor glycemic control. Good glycemic management to control the plasma levels of PAI‐1 is required to prevent hypercoagulability and thrombotic disorders.

Published in Health Science Reports

ISSN: 2398-8835 (Online)
Publisher: Wiley
Country of publisher: United States
LCC subjects: Medicine
Website: https://onlinelibrary.wiley.com/journal/23988835

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