The applicability of sulfoxide Michael acceptor – 2­-(S)-­[(4­-methylphenyl)sulfinyl]-­2­-cyclopenten­-1­-one in constructing the carbon skeleton of 9,11­-secosterols

Abstract

A possibility of use of the Michael addition reaction of the A,B­-ring fragment enolate to sulfoxide 2­-(S)-­[(4­-methylphenyl)sulfinyl]-­2­-cyclopenten­-1­-one for constructing the main skeleton of 9,11­-secosterols was studied. The reaction was conducted with the racemic or the enantiomerically enriched sulfoxide as the acceptor, affording a mixture of five or three main diastereomers, respectively. It was shown that the diastereoselectivity of that addition reaction is relatively low and does not afford a competitive new route for the total synthesis of secosterols.

Keywords

• michael addition
• sulfoxides
• 9
• 11­-secosterols.