Crescent Journal of Medical and Biological Sciences (Oct 2019)
The Effect of Hydroalchoholic Extract of Cinnamon zeylanicum on Oxidative Damages and Biochemical Change in Adult Rats With Polycystic Ovary Syndrome
Abstract
Objectives: Polycystic ovary syndrome (PCOS) is known as one of the most usual hormone disorder in women of childbearing age. Accordingly, the aim of this research was to investigate the effect of hydroalchoholic extract of Cinnamon zeylanicum (CZ) on oxidative damages and biochemical change in adult rats with PCOS. Materials and Methods: In our experimental research, 32 Wistar female rats were used (n=8 per group) including control group (G1), PCOS group without any therapy (G2), rats with PCOS that received a daily intake of hydroalcoholic extract (the 200 mg/kg/orally) of CZ for 2 weeks (G3), and the group with no PCOS while with a daily intake of the extract of CZ (200 mg/kg) for 2 weeks (G4). PCOS was induced by estradiol valerate with a single injection dose (16 mg/kg) intramuscularly. After 14 days, all animals were anesthetized with ketamine and xylazine, followed by obtaining the blood sample and using their plasma for checking the blood glucose, insulin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen, and testosterone. Finally, the ovaries of all animals were removed and fixed for assessing the histological damage. Results: As regards the plasma levels of blood glucose, insulin, LH, FSH, and testosterone, a significant change was observed between G2 and G1 groups while G3 and G4 groups demonstrated a significant decline in terms of such parameters as compared to G2 group. In addition, the level of estrogen in the plasma decreased significantly in G2 as compared to G1 while in G2 and G1, it was significantly higher when compared to the PCOS group. Eventually, the number of follicles reduced in PCOS group while it indicated an increase in the groups which were treated with CZ extract. Conclusions: The results of the present research showed that the hydroalcoholic extract of CZ has a beneficial effect on regulating the plasma levels of testosterone, estradiol, LH, FSH, FBS, and insulin in the palliation of PCOS complications.
