G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression

Xi Zhang; Danni Peng; Yuanxin Xi; Chao Yuan; Cari A. Sagum; Brianna J. Klein; Kaori Tanaka; Hong Wen; Tatiana G. Kutateladze; Wei Li; Mark T. Bedford; Xiaobing Shi

doi:10.1038/ncomms10810

Nature Communications (Mar 2016)

G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression

Xi Zhang,
Danni Peng,
Yuanxin Xi,
Chao Yuan,
Cari A. Sagum,
Brianna J. Klein,
Kaori Tanaka,
Hong Wen,
Tatiana G. Kutateladze,
Wei Li,
Mark T. Bedford,
Xiaobing Shi

Affiliations

Xi Zhang: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Danni Peng: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Yuanxin Xi: Department of Molecular and Cellular Biology, Dan L. Duncan Cancer Center, Baylor College of Medicine
Chao Yuan: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Cari A. Sagum: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Brianna J. Klein: Department of Pharmacology, University of Colorado School of Medicine
Kaori Tanaka: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Hong Wen: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Tatiana G. Kutateladze: Department of Pharmacology, University of Colorado School of Medicine
Wei Li: Department of Molecular and Cellular Biology, Dan L. Duncan Cancer Center, Baylor College of Medicine
Mark T. Bedford: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Xiaobing Shi: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/ncomms10810
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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The histone methyltransferase G9a methylates histone H3K9 to repress gene expression, but it also acts as a coactivator for some nuclear receptors. Here, Zhang et al. show that methylation of ERα by G9a recruits the PHF20/MOF complex that deposits histone H4K16 acetylation promoting active transcription.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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