Nature Communications (Aug 2019)
Structural basis for delta cell paracrine regulation in pancreatic islets
- Rafael Arrojo e Drigo,
- Stefan Jacob,
- Concha F. García-Prieto,
- Xiaofeng Zheng,
- Masahiro Fukuda,
- Hoa Tran Thi Nhu,
- Olga Stelmashenko,
- Flavia Letícia Martins Peçanha,
- Rayner Rodriguez-Diaz,
- Eric Bushong,
- Thomas Deerinck,
- Sebastien Phan,
- Yusuf Ali,
- Ingo Leibiger,
- Minni Chua,
- Thomas Boudier,
- Sang-Ho Song,
- Martin Graf,
- George J. Augustine,
- Mark H. Ellisman,
- Per-Olof Berggren
Affiliations
- Rafael Arrojo e Drigo
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Stefan Jacob
- Karolinska Intitutet, The Rolf Luft Research Center for Diabetes and Endocrinology
- Concha F. García-Prieto
- Karolinska Intitutet, The Rolf Luft Research Center for Diabetes and Endocrinology
- Xiaofeng Zheng
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Masahiro Fukuda
- Molecular Neurophysiology Laboratory, Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School
- Hoa Tran Thi Nhu
- Bioinformatics Institute (ASTAR) and Image and Pervasive Access Lab (IPAL)
- Olga Stelmashenko
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Flavia Letícia Martins Peçanha
- Universidade Federal do Rio de Janeiro (UFRJ)
- Rayner Rodriguez-Diaz
- Miller School of Medicine, University of Miami
- Eric Bushong
- National Center for Microscopy and Imaging Research (NCMIR), University of California San Diego
- Thomas Deerinck
- National Center for Microscopy and Imaging Research (NCMIR), University of California San Diego
- Sebastien Phan
- National Center for Microscopy and Imaging Research (NCMIR), University of California San Diego
- Yusuf Ali
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Ingo Leibiger
- Karolinska Intitutet, The Rolf Luft Research Center for Diabetes and Endocrinology
- Minni Chua
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Thomas Boudier
- Bioinformatics Institute (ASTAR) and Image and Pervasive Access Lab (IPAL)
- Sang-Ho Song
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Martin Graf
- Lee Kong Chian School of Medicine, Nanyang Technological University
- George J. Augustine
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Mark H. Ellisman
- National Center for Microscopy and Imaging Research (NCMIR), University of California San Diego
- Per-Olof Berggren
- Lee Kong Chian School of Medicine, Nanyang Technological University
- DOI
- https://doi.org/10.1038/s41467-019-11517-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Pancreatic islets are composed of alpha-, beta-, as well as delta-cells and appropriate regulation of glucose homeostasis relies on auto- and paracrine cellular communication. Here, the authors study the role of delta-cell filopodia in this context by employing optogenetic and calcium imaging approaches.
