Nature Communications (Aug 2016)
Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane
- Peter J. Wen,
- Staffan Grenklo,
- Gianvito Arpino,
- Xinyu Tan,
- Hsien-Shun Liao,
- Johanna Heureaux,
- Shi-Yong Peng,
- Hsueh-Cheng Chiang,
- Edaeni Hamid,
- Wei-Dong Zhao,
- Wonchul Shin,
- Tuomas Näreoja,
- Emma Evergren,
- Yinghui Jin,
- Roger Karlsson,
- Steven N. Ebert,
- Albert Jin,
- Allen P. Liu,
- Oleg Shupliakov,
- Ling-Gang Wu
Affiliations
- Peter J. Wen
- National Institute of Neurological Disorders and Stroke
- Staffan Grenklo
- Department of Neuroscience, Center of Excellence in Developmental Biology, Karolinska Institutet
- Gianvito Arpino
- National Institute of Neurological Disorders and Stroke
- Xinyu Tan
- Department of Mechanical Engineering, University of Michigan
- Hsien-Shun Liao
- National Institute of Biomedical Imaging and Bioengineering (NIBIB)
- Johanna Heureaux
- Department of Mechanical Engineering, University of Michigan
- Shi-Yong Peng
- National Institute of Neurological Disorders and Stroke
- Hsueh-Cheng Chiang
- National Institute of Neurological Disorders and Stroke
- Edaeni Hamid
- National Institute of Neurological Disorders and Stroke
- Wei-Dong Zhao
- National Institute of Neurological Disorders and Stroke
- Wonchul Shin
- National Institute of Neurological Disorders and Stroke
- Tuomas Näreoja
- Department of Neuroscience, Center of Excellence in Developmental Biology, Karolinska Institutet
- Emma Evergren
- Department of Neuroscience, Center of Excellence in Developmental Biology, Karolinska Institutet
- Yinghui Jin
- National Institute of Neurological Disorders and Stroke
- Roger Karlsson
- Department of Cell Biology, WGI, Stockholm University
- Steven N. Ebert
- Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida
- Albert Jin
- National Institute of Biomedical Imaging and Bioengineering (NIBIB)
- Allen P. Liu
- Department of Mechanical Engineering, University of Michigan
- Oleg Shupliakov
- Department of Neuroscience, Center of Excellence in Developmental Biology, Karolinska Institutet
- Ling-Gang Wu
- National Institute of Neurological Disorders and Stroke
- DOI
- https://doi.org/10.1038/ncomms12604
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
As vesicles fuse to the plasma membrane, they form intermediate Ω-shaped structures followed by either closure of the pore or full merging with the plasma membrane. Here Wen et al. show that dynamic actin assembly provides membrane tension to promote Ω merging in neuroendocrine cells and synapses.
