Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life

Torleif Tollefsrud Gjølberg; Rahel Frick; Simone Mester; Stian Foss; Algirdas Grevys; Lene Støkken Høydahl; Øystein Kalsnes Jørstad; Tilman Schlothauer; Inger Sandlie; Morten C. Moe; Jan Terje Andersen

doi:10.1038/s42003-022-03787-x

Communications Biology (Aug 2022)

Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life

Torleif Tollefsrud Gjølberg,
Rahel Frick,
Simone Mester,
Stian Foss,
Algirdas Grevys,
Lene Støkken Høydahl,
Øystein Kalsnes Jørstad,
Tilman Schlothauer,
Inger Sandlie,
Morten C. Moe,
Jan Terje Andersen

Affiliations

Torleif Tollefsrud Gjølberg: Department of Immunology, Oslo University Hospital, Rikshospitalet
Rahel Frick: Department of Chemical and Biomolecular Engineering, Johns Hopkins University
Simone Mester: Department of Immunology, Oslo University Hospital, Rikshospitalet
Stian Foss: Department of Immunology, Oslo University Hospital, Rikshospitalet
Algirdas Grevys: Department of Immunology, Oslo University Hospital, Rikshospitalet
Lene Støkken Høydahl: Department of Immunology, Oslo University Hospital, Rikshospitalet
Øystein Kalsnes Jørstad: Department of Ophthalmology, Oslo University Hospital, University of Oslo
Tilman Schlothauer: Roche Pharma Research and Early Development (pRED), Roche Innovation Center Munich
Inger Sandlie: Department of Biosciences, University of Oslo
Morten C. Moe: Department of Ophthalmology, Oslo University Hospital, University of Oslo
Jan Terje Andersen: Department of Immunology, Oslo University Hospital, Rikshospitalet

DOI: https://doi.org/10.1038/s42003-022-03787-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 17

Abstract

Read online

Analysis of clinically approved antibody-based therapeutics reveals different structural designs, such as full-length IgG1 or Fc-fusions, entail distinct biophysical properties that affect FcRn binding, intracellular transport and plasma half-life.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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