Frontiers in Immunology (Aug 2022)

Colorectal cancer vaccines: The current scenario and future prospects

  • Wenqing Jia,
  • Wenqing Jia,
  • Tao Zhang,
  • Tao Zhang,
  • Haiyan Huang,
  • Haiyan Huang,
  • Haoran Feng,
  • Haoran Feng,
  • Shaodong Wang,
  • Shaodong Wang,
  • Zichao Guo,
  • Zichao Guo,
  • Zhiping Luo,
  • Zhiping Luo,
  • Xiaopin Ji,
  • Xiaopin Ji,
  • Xi Cheng,
  • Xi Cheng,
  • Ren Zhao,
  • Ren Zhao

DOI
https://doi.org/10.3389/fimmu.2022.942235
Journal volume & issue
Vol. 13

Abstract

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Colorectal cancer (CRC) is one of the most common cancers worldwide. Current therapies such as surgery, chemotherapy, and radiotherapy encounter obstacles in preventing metastasis of CRC even when applied in combination. Immune checkpoint inhibitors depict limited effects due to the limited cases of CRC patients with high microsatellite instability (MSI-H). Cancer vaccines are designed to trigger the elevation of tumor-infiltrated lymphocytes, resulting in the intense response of the immune system to tumor antigens. This review briefly summarizes different categories of CRC vaccines, demonstrates the current outcomes of relevant clinical trials, and provides particular focus on recent advances on nanovaccines and neoantigen vaccines, representing the trend and emphasis of CRC vaccine development.

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