Frontiers in Chemistry (Jun 2022)
Novel Coumarin–Pyridine Hybrids as Potent Multi-Target Directed Ligands Aiming at Symptoms of Alzheimer’s Disease
- Elaheh Babaei,
- Tuba Tüylü Küçükkılınç,
- Leili Jalili-Baleh,
- Hamid Nadri,
- Esin Öz,
- Hamid Forootanfar,
- Elaheh Hosseinzadeh,
- Tayebeh Akbari,
- Mehdi Shafiee Ardestani,
- Loghman Firoozpour,
- Alireza Foroumadi,
- Mohammad Sharifzadeh,
- Bi Bi Fatemeh Mirjalili,
- Mehdi Khoobi,
- Mehdi Khoobi
Affiliations
- Elaheh Babaei
- Department of Chemistry, Faculty of Science, Yazd University, Yazd, Iran
- Tuba Tüylü Küçükkılınç
- Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
- Leili Jalili-Baleh
- Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran University of Medical Science, Tehran, Iran
- Hamid Nadri
- Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
- Esin Öz
- Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
- Hamid Forootanfar
- Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
- Elaheh Hosseinzadeh
- The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
- Tayebeh Akbari
- Department of Microbiology, Islamic Azad University, North Tehran Branch, Tehran, Iran
- Mehdi Shafiee Ardestani
- Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
- Loghman Firoozpour
- Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran University of Medical Science, Tehran, Iran
- Alireza Foroumadi
- Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran University of Medical Science, Tehran, Iran
- Mohammad Sharifzadeh
- Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
- Bi Bi Fatemeh Mirjalili
- Department of Chemistry, Faculty of Science, Yazd University, Yazd, Iran
- Mehdi Khoobi
- The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
- Mehdi Khoobi
- Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
- DOI
- https://doi.org/10.3389/fchem.2022.895483
- Journal volume & issue
-
Vol. 10
Abstract
Graphical AbstractA novel series of 3-phenyl-coumarin derivatives containing pyridinium salts was prepared, indicating significant inhibitory activity against AChE and BuChE as well as precious neuroprotective and anti-Aβ aggregation effects.
Keywords
- Alzheimer’s disease
- cholinesterase inhibitors
- coumarin derivatives
- neurodegenerative diseases
- docking study
