Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer

• Gerhard Rogler,
• Arndt Hartmann,
• Marianne Rebecca Spalinger,
• Michael Scharl,
• Elisabeth Naschberger,
• Jesus Francisco Glaus Garzon,
• Silvia Lang,
• Kirstin Atrott,
• Philipp Busenhart,
• Ana Montalban-Arques,
• Egle Katkeviciute,
• Yasser Morsy,
• Chiara Van Passen,
• Larissa Hering,
• Michael Stürzl

Affiliations

Gerhard Rogler

1 Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Arndt Hartmann

4 Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

Marianne Rebecca Spalinger

1 Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Michael Scharl

1 Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Elisabeth Naschberger

2 Division of Molecular and Experimental Surgery, Department of Surgery, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

Jesus Francisco Glaus Garzon

3 Department of Physiology, University of Zurich, Zurich, Switzerland

Silvia Lang

1 Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Kirstin Atrott

1 Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Philipp Busenhart

1 Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Ana Montalban-Arques

1 Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Egle Katkeviciute

1 Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Yasser Morsy

1 Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Chiara Van Passen

2 Division of Molecular and Experimental Surgery, Department of Surgery, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

Larissa Hering

1 Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Michael Stürzl

2 Division of Molecular and Experimental Surgery, Department of Surgery, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany