Prevention and predictive nursing activity of Cu(II) coordination polymer on hypothermia during laparoscopic cholecystectomy operation

Abstract

Abstract In this study, through employing the mixed‐ligand synthesis method, a novel coordination polymer (CP) containing Cu(II) has been synthesized in success with the reaction of 4‐bmbpd and Cu(NO3)2·3H2O in the presence of auxiliary polycarboxylate ligand 1,3,5‐H3BTC under hydrothermal conditions, and the chemical formula of this compound is [Cu(4‐bmbpd)(1,3,5‐HBTC)]·2H2O (1) (1,3,5‐H3BTC is 1,3,5‐benzenetricarboxylic acid and 4‐bmbpd is N,N′‐bis(4‐methylenepyridin‐4‐yl)‐1,4‐benzenedicarboxamide). The assessment of its prevention and predictive nursing activity on the hypothermia during laparoscopic cholecystectomy operation was conducted and the corresponding mechanism was studied simultaneously. The molecular docking simulation helps for identifying that the carboxylate group and the amide group form multiple H‐bonds with respect to the active sites within the docking pocket of the target protein.