Cellular and gene signatures of tumor-infiltrating dendritic cells and natural-killer cells predict prognosis of neuroblastoma

Ombretta Melaiu; Marco Chierici; Valeria Lucarini; Giuseppe Jurman; Libenzio Adrian Conti; Rita De Vito; Renata Boldrini; Loredana Cifaldi; Aurora Castellano; Cesare Furlanello; Vincenzo Barnaba; Franco Locatelli; Doriana Fruci

doi:10.1038/s41467-020-19781-y

Nature Communications (Nov 2020)

Cellular and gene signatures of tumor-infiltrating dendritic cells and natural-killer cells predict prognosis of neuroblastoma

Ombretta Melaiu,
Marco Chierici,
Valeria Lucarini,
Giuseppe Jurman,
Libenzio Adrian Conti,
Rita De Vito,
Renata Boldrini,
Loredana Cifaldi,
Aurora Castellano,
Cesare Furlanello,
Vincenzo Barnaba,
Franco Locatelli,
Doriana Fruci

Affiliations

Ombretta Melaiu: Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Ospedale Pediatrico Bambino Gesù, IRCCS
Marco Chierici: Fondazione Bruno Kessler
Valeria Lucarini: Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Ospedale Pediatrico Bambino Gesù, IRCCS
Giuseppe Jurman: Fondazione Bruno Kessler
Libenzio Adrian Conti: Confocal microscopy, Core Facility, Research Laboratories, Ospedale Pediatrico Bambino Gesù, IRCCS
Rita De Vito: Department of Pathology, Bambino Gesù Children’s Hospital
Renata Boldrini: Department of Pathology, Bambino Gesù Children’s Hospital
Loredana Cifaldi: Academic Department of Pediatrics (DPUO), Ospedale Pediatrico Bambino Gesù, IRCCS
Aurora Castellano: Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Ospedale Pediatrico Bambino Gesù, IRCCS
Cesare Furlanello: Fondazione Bruno Kessler
Vincenzo Barnaba: Cellular and Molecular Immunology Unit, Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardiovascolari, Sapienza University of Rome
Franco Locatelli: Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Ospedale Pediatrico Bambino Gesù, IRCCS
Doriana Fruci: Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Ospedale Pediatrico Bambino Gesù, IRCCS

DOI: https://doi.org/10.1038/s41467-020-19781-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Tumour-infiltrating lymphocytes play a crucial role in neuroblastoma, but their relationship to other immune cells is poorly understood. Here the authors identify the cellular and gene signatures of intratumoural dendritic cells and natural killer cells that predict the clinical outcome of neuroblastoma.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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