Frontiers in Neurology (Dec 2021)
Enhancing Safety in Epilepsy Surgery (EASINESS): Study Protocol for a Retrospective, Multicenter, Open Registry
- Richard Drexler,
- Sharona Ben-Haim,
- Christian G. Bien,
- Valeri Borger,
- Francesco Cardinale,
- Alexandre Carpentier,
- Fernando Cendes,
- Sarat Chandra,
- Hans Clusmann,
- Albert Colon,
- Marco de Curtis,
- Daniel Delev,
- Giuseppe Didato,
- Lasse Dührsen,
- Jibril Osman Farah,
- Marc Guenot,
- Marc Guenot,
- Saadi Ghatan,
- Claire Haegelen,
- Claire Haegelen,
- Hajo Hamer,
- Jason S. Hauptmann,
- Rosalind L. Jeffree,
- Rosalind L. Jeffree,
- Thilo Kalbhenn,
- Josua Kegele,
- Niklaus Krayenbühl,
- Johannes Lang,
- Bertrand Mathon,
- Georgios Naros,
- Julia Onken,
- Fedor Panov,
- Christian Raftopoulos,
- Franz L. Ricklefs,
- Kim Rijkers,
- Michele Rizzi,
- Karl Rössler,
- Olaf Schijns,
- Olaf Schijns,
- Ulf C. Schneider,
- Andrea Spyrantis,
- Adam Strzelczyk,
- Stefan Stodieck,
- Manjari Tripathi,
- Sumeet Vadera,
- Mario A. Alonso-Vanegas,
- José Géraldo Ribero Vaz,
- Jörg Wellmer,
- Tim Wehner,
- Manfred Westphal,
- Thomas Sauvigny
Affiliations
- Richard Drexler
- Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Sharona Ben-Haim
- Department of Neurosurgery, University of California San Diego, San Diego, CA, United States
- Christian G. Bien
- Epilepsy Centre Bethel, Krankenhaus Mara, Bielefeld, Germany
- Valeri Borger
- Department of Neurosurgery, University Hospital Bonn, Bonn, Germany
- Francesco Cardinale
- “C. Munari” Epilepsy Surgery Center, Niguarda Hospital, Milan, Italy
- Alexandre Carpentier
- Department of Neurosurgery, Pitié-Salpêtrière Hospital, Paris, France
- Fernando Cendes
- Department of Neurology, University of Campinas, Campinas, Brazil
- Sarat Chandra
- Department of Neurosurgery, AIIMS, New Delhi, India
- Hans Clusmann
- Department of Neurosurgery, University Hospital RWTH Aachen, Aachen, Germany
- Albert Colon
- 0School for Mental Health and Neuroscience (MHeNS), University Maastricht (UM), Maastricht, Netherlands
- Marco de Curtis
- 1Epilepsy Unit, IRCCS “C. Besta” Neurological Institute Foundation, Milan, Italy
- Daniel Delev
- Department of Neurosurgery, University Hospital RWTH Aachen, Aachen, Germany
- Giuseppe Didato
- 1Epilepsy Unit, IRCCS “C. Besta” Neurological Institute Foundation, Milan, Italy
- Lasse Dührsen
- Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Jibril Osman Farah
- 2The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom
- Marc Guenot
- 3Department of Functional Neurosurgery, P. Wertheimer Hospital, Hospices Civils de Lyon, Lyon, France
- Marc Guenot
- 4Department for Neurosurgery, University of Lyon, Lyon, France
- Saadi Ghatan
- 5Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Claire Haegelen
- 3Department of Functional Neurosurgery, P. Wertheimer Hospital, Hospices Civils de Lyon, Lyon, France
- Claire Haegelen
- 4Department for Neurosurgery, University of Lyon, Lyon, France
- Hajo Hamer
- 6Epilepsy Center, Department of Neurology, University of Erlangen-Nürnberg, Erlangen, Germany
- Jason S. Hauptmann
- 7Department of Neurosurgery, University of Washington, Seattle, WA, United States
- Rosalind L. Jeffree
- 8Department of Neurosurgery, Royal Brisbane and Womens Hospital, Brisbane, QLD, Australia
- Rosalind L. Jeffree
- 9Herston Clinical School, University of Queensland, Brisbane, QLD, Australia
- Thilo Kalbhenn
- 0Department of Neurosurgery (Evangelisches Klinikum Bethel), Bielefeld University, Medical School, Bielefeld, Germany
- Josua Kegele
- 1Department of Neurology and Epileptology, Hertie Institute of Clinical Brain Research, University of Tubingen, Tubingen, Germany
- Niklaus Krayenbühl
- 2Division of Pediatric Neurosurgery, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland
- Johannes Lang
- 6Epilepsy Center, Department of Neurology, University of Erlangen-Nürnberg, Erlangen, Germany
- Bertrand Mathon
- Department of Neurosurgery, Pitié-Salpêtrière Hospital, Paris, France
- Georgios Naros
- 1Department of Neurology and Epileptology, Hertie Institute of Clinical Brain Research, University of Tubingen, Tubingen, Germany
- Julia Onken
- 3Department of Neurosurgery, Universitätsmedizin Charité-Berlin, Berlin, Germany
- Fedor Panov
- 5Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Christian Raftopoulos
- 4Department of Neurosurgery, University Hospital St-Luc, Université Catholique de Louvain (UCL), Brussels, Belgium
- Franz L. Ricklefs
- Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Kim Rijkers
- 5Department of Neurosurgery, Academic Center for Epileptology UMC Maastricht, Maastricht, Netherlands
- Michele Rizzi
- 6Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- Karl Rössler
- 7Department of Neurosurgery, Medical University Vienna, Vienna, Austria
- Olaf Schijns
- 5Department of Neurosurgery, Academic Center for Epileptology UMC Maastricht, Maastricht, Netherlands
- Olaf Schijns
- 8School for Mental Health and Neuroscience (MHeNS), University Maastricht (UM), Maastricht, Netherlands
- Ulf C. Schneider
- 3Department of Neurosurgery, Universitätsmedizin Charité-Berlin, Berlin, Germany
- Andrea Spyrantis
- 9Department of Neurosurgery and Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, Goethe-University Frankfurt, Frankfurt, Germany
- Adam Strzelczyk
- 9Department of Neurosurgery and Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, Goethe-University Frankfurt, Frankfurt, Germany
- Stefan Stodieck
- 0Hamburg Epilepsy Center, Protestant Hospital Alsterdorf, Department of Neurology and Epileptology, Hamburg, Germany
- Manjari Tripathi
- Department of Neurosurgery, AIIMS, New Delhi, India
- Sumeet Vadera
- 1Department of Neurological Surgery, University of California Irvine, Irvine, CA, United States
- Mario A. Alonso-Vanegas
- 2National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez, Mexico City, Mexico
- José Géraldo Ribero Vaz
- 4Department of Neurosurgery, University Hospital St-Luc, Université Catholique de Louvain (UCL), Brussels, Belgium
- Jörg Wellmer
- 3Ruhr - Epileptology, Department of Neurology, University Hospital Knappschafts-Krankenhaus, Ruhr - University Bochum, Bochum, Germany
- Tim Wehner
- 3Ruhr - Epileptology, Department of Neurology, University Hospital Knappschafts-Krankenhaus, Ruhr - University Bochum, Bochum, Germany
- Manfred Westphal
- Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Thomas Sauvigny
- Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- DOI
- https://doi.org/10.3389/fneur.2021.782666
- Journal volume & issue
-
Vol. 12
Abstract
Introduction: Optimizing patient safety and quality improvement is increasingly important in surgery. Benchmarks and clinical quality registries are being developed to assess the best achievable results for several surgical procedures and reduce unwarranted variation between different centers. However, there is no clinical database from international centers for establishing standardized reference values of patients undergoing surgery for mesial temporal lobe epilepsy.Design: The Enhancing Safety in Epilepsy Surgery (EASINESS) study is a retrospectively conducted, multicenter, open registry. All patients undergoing mesial temporal lobe epilepsy surgery in participating centers between January 2015 and December 2019 are included in this study. The patient characteristics, preoperative diagnostic tools, surgical data, postoperative complications, and long-term seizure outcomes are recorded.Outcomes: The collected data will be used for establishing standardized reference values (“benchmarks”) for this type of surgical procedure. The primary endpoints include seizure outcomes according to the International League Against Epilepsy (ILAE) classification and defined postoperative complications.Discussion: The EASINESS will define robust and standardized outcome references after amygdalohippocampectomy for temporal lobe epilepsy. After the successful definition of benchmarks from an international cohort of renowned centers, these data will serve as reference values for the evaluation of novel surgical techniques and comparisons among centers for future clinical trials.Clinical trial registration: This study is indexed at clinicaltrials.gov (NT 04952298).
Keywords
