Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis

Tomoyuki Mutoh; Tsuyoshi Shirai; Tomonori Ishii; Yuko Shirota; Fumiyoshi Fujishima; Fumiaki Takahashi; Yoichi Kakuta; Yoshitake Kanazawa; Atsushi Masamune; Yoshikatsu Saiki; Hideo Harigae; Hiroshi Fujii

doi:10.1038/s41467-020-15088-0

Nature Communications (Mar 2020)

Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis

Tomoyuki Mutoh,
Tsuyoshi Shirai,
Tomonori Ishii,
Yuko Shirota,
Fumiyoshi Fujishima,
Fumiaki Takahashi,
Yoichi Kakuta,
Yoshitake Kanazawa,
Atsushi Masamune,
Yoshikatsu Saiki,
Hideo Harigae,
Hiroshi Fujii

Affiliations

Tomoyuki Mutoh: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
Tsuyoshi Shirai: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
Tomonori Ishii: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
Yuko Shirota: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
Fumiyoshi Fujishima: Department of Anatomic Pathology, Tohoku University Graduate School of Medicine
Fumiaki Takahashi: Division of Medical Engineering, Department of Information Science, Iwate Medical University
Yoichi Kakuta: Division of Gastroenterology, Tohoku University Graduate School of Medicine
Yoshitake Kanazawa: Division of Gastroenterology, Tohoku University Graduate School of Medicine
Atsushi Masamune: Division of Gastroenterology, Tohoku University Graduate School of Medicine
Yoshikatsu Saiki: Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine
Hideo Harigae: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
Hiroshi Fujii: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine

DOI: https://doi.org/10.1038/s41467-020-15088-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Autoantibodies against endothelium have been recognized in Takayasu arteritis (TAK). Here the authors identify endothelial protein C receptor and scavenger receptor class B type 1 as major autoantigens in TAK, and find autoantibodies inhibit the negative regulation of endothelial activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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