CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation

Shangcheng Xu; Pei Wang; Huiliang Zhang; Guohua Gong; Nicolas Gutierrez Cortes; Weizhong Zhu; Yisang Yoon; Rong Tian; Wang Wang

doi:10.1038/ncomms13189

Nature Communications (Oct 2016)

CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation

Shangcheng Xu,
Pei Wang,
Huiliang Zhang,
Guohua Gong,
Nicolas Gutierrez Cortes,
Weizhong Zhu,
Yisang Yoon,
Rong Tian,
Wang Wang

Affiliations

Shangcheng Xu: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington
Pei Wang: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington
Huiliang Zhang: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington
Guohua Gong: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington
Nicolas Gutierrez Cortes: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington
Weizhong Zhu: Nantong University School of Pharmacy
Yisang Yoon: Department of Physiology, Georgia Regents University
Rong Tian: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington
Wang Wang: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington

DOI: https://doi.org/10.1038/ncomms13189
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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β-adrenergic receptor signaling induces mitochondrial permeability transition pore (mPTP) opening. Here, Xuet al. show that this effect is mediated by phosphorylation of mitochondrial fission protein Drp1 by CamKII, which increases the frequency of transient mPTP opening.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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