Nature Communications (Feb 2022)
Stroke induces disease-specific myeloid cells in the brain parenchyma and pia
- Carolin Beuker,
- David Schafflick,
- Jan-Kolja Strecker,
- Michael Heming,
- Xiaolin Li,
- Jolien Wolbert,
- Antje Schmidt-Pogoda,
- Christian Thomas,
- Tanja Kuhlmann,
- Irene Aranda-Pardos,
- Noelia A-Gonzalez,
- Praveen Ashok Kumar,
- Yves Werner,
- Ertugrul Kilic,
- Dirk M. Hermann,
- Heinz Wiendl,
- Ralf Stumm,
- Gerd Meyer zu Hörste,
- Jens Minnerup
Affiliations
- Carolin Beuker
- Department of Neurology with Institute of Translational Neurology, Medical Faculty, University Hospital
- David Schafflick
- Department of Neurology with Institute of Translational Neurology, Medical Faculty, University Hospital
- Jan-Kolja Strecker
- Department of Neurology with Institute of Translational Neurology, Medical Faculty, University Hospital
- Michael Heming
- Department of Neurology with Institute of Translational Neurology, Medical Faculty, University Hospital
- Xiaolin Li
- Department of Neurology with Institute of Translational Neurology, Medical Faculty, University Hospital
- Jolien Wolbert
- Department of Neurology with Institute of Translational Neurology, Medical Faculty, University Hospital
- Antje Schmidt-Pogoda
- Department of Neurology with Institute of Translational Neurology, Medical Faculty, University Hospital
- Christian Thomas
- Institute of Neuropathology, University of Münster
- Tanja Kuhlmann
- Institute of Neuropathology, University of Münster
- Irene Aranda-Pardos
- Institute of Immunology, Westfälische Wilhelms-University
- Noelia A-Gonzalez
- Institute of Immunology, Westfälische Wilhelms-University
- Praveen Ashok Kumar
- Institute of Pharmacology and Toxicology, Jena University Hospital
- Yves Werner
- Institute of Pharmacology and Toxicology, Jena University Hospital
- Ertugrul Kilic
- Istanbul Medipol University Regenerative and Restorative Medical Research Center
- Dirk M. Hermann
- Department of Neurology, University Hospital Essen
- Heinz Wiendl
- Department of Neurology with Institute of Translational Neurology, Medical Faculty, University Hospital
- Ralf Stumm
- Institute of Pharmacology and Toxicology, Jena University Hospital
- Gerd Meyer zu Hörste
- Department of Neurology with Institute of Translational Neurology, Medical Faculty, University Hospital
- Jens Minnerup
- Department of Neurology with Institute of Translational Neurology, Medical Faculty, University Hospital
- DOI
- https://doi.org/10.1038/s41467-022-28593-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
How ischaemic stroke affects the brain borders is not fully understood. Here the authors show that a stroke-associated myeloid cell population occurs exclusively in brain parenchyma that shares features with neurodegenerative microglia and blockade of proteins on these cells can ameliorate stroke symptoms.
