Nature Communications (Oct 2018)
Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells
- Oliver A. Stone,
- Mohamed El-Brolosy,
- Kerstin Wilhelm,
- Xiaojing Liu,
- Ana M. Romão,
- Elisabetta Grillo,
- Jason K. H. Lai,
- Stefan Günther,
- Sylvia Jeratsch,
- Carsten Kuenne,
- I-Ching Lee,
- Thomas Braun,
- Massimo M. Santoro,
- Jason W. Locasale,
- Michael Potente,
- Didier Y. R. Stainier
Affiliations
- Oliver A. Stone
- Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
- Mohamed El-Brolosy
- Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
- Kerstin Wilhelm
- Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research
- Xiaojing Liu
- Department of Pharmacology and Cancer Biology, Duke University School of Medicine
- Ana M. Romão
- Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research
- Elisabetta Grillo
- Department of Oncology, KUL
- Jason K. H. Lai
- Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
- Stefan Günther
- ECCPS Bioinformatics and Deep Sequencing Platform, Max Planck Institute for Heart and Lung Research
- Sylvia Jeratsch
- Biomolecular Mass Spectrometry, Max Planck Institute for Heart and Lung Research
- Carsten Kuenne
- ECCPS Bioinformatics and Deep Sequencing Platform, Max Planck Institute for Heart and Lung Research
- I-Ching Lee
- Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
- Thomas Braun
- Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research
- Massimo M. Santoro
- Department of Biology, University of Padua
- Jason W. Locasale
- Department of Pharmacology and Cancer Biology, Duke University School of Medicine
- Michael Potente
- Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research
- Didier Y. R. Stainier
- Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
- DOI
- https://doi.org/10.1038/s41467-018-06406-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
The glycolytic enzyme pyruvate kinase M2 (PKM2) is required for nucleotide synthesis and cell proliferation. Using gene expression and metabolomics analyses, the authors here show that PKM2 regulates methionine metabolism and DNA methylation in endothelial cells.
