Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression

Swathi V. Iyer; Atul Ranjan; Harold K. Elias; Alejandro Parrales; Hiromi Sasaki; Badal C. Roy; Shahid Umar; Ossama W. Tawfik; Tomoo Iwakuma

doi:10.1038/ncomms13561

Nature Communications (Nov 2016)

Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression

Swathi V. Iyer,
Atul Ranjan,
Harold K. Elias,
Alejandro Parrales,
Hiromi Sasaki,
Badal C. Roy,
Shahid Umar,
Ossama W. Tawfik,
Tomoo Iwakuma

Affiliations

Swathi V. Iyer: Department of Cancer Biology, University of Kansas Medical Center
Atul Ranjan: Department of Cancer Biology, University of Kansas Medical Center
Harold K. Elias: Department of Internal Medicine, Icahn School of Medicine at Mount Sinai
Alejandro Parrales: Department of Cancer Biology, University of Kansas Medical Center
Hiromi Sasaki: Department of Cancer Biology, University of Kansas Medical Center
Badal C. Roy: Department of Surgery, University of Kansas Medical Center
Shahid Umar: Department of Surgery, University of Kansas Medical Center
Ossama W. Tawfik: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center
Tomoo Iwakuma: Department of Cancer Biology, University of Kansas Medical Center

DOI: https://doi.org/10.1038/ncomms13561
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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The ability of cancer cells to survive in anchorage-independent conditions correlates with cancer aggressiveness. Here, by screening a human whole-genome shRNA library for the ability of osteosarcoma cells to form spheres in vitro, the authors identify a role for TMIGD3 isoform 1 in suppressing the metastatic potential of osteosarcoma.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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