Nature Communications (Dec 2021)
Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut
- Judith Behnsen,
- Hui Zhi,
- Allegra T. Aron,
- Vivekanandan Subramanian,
- William Santus,
- Michael H. Lee,
- Romana R. Gerner,
- Daniel Petras,
- Janet Z. Liu,
- Keith D. Green,
- Sarah L. Price,
- Jose Camacho,
- Hannah Hillman,
- Joshua Tjokrosurjo,
- Nicola P. Montaldo,
- Evelyn M. Hoover,
- Sean Treacy-Abarca,
- Benjamin A. Gilston,
- Eric P. Skaar,
- Walter J. Chazin,
- Sylvie Garneau-Tsodikova,
- Matthew B. Lawrenz,
- Robert D. Perry,
- Sean-Paul Nuccio,
- Pieter C. Dorrestein,
- Manuela Raffatellu
Affiliations
- Judith Behnsen
- Department of Microbiology & Molecular Genetics, University of California Irvine
- Hui Zhi
- Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego
- Allegra T. Aron
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
- Vivekanandan Subramanian
- University of Kentucky PharmNMR Center, College of Pharmacy, University of Kentucky
- William Santus
- Department of Microbiology & Immunology, University of Illinois Chicago
- Michael H. Lee
- Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego
- Romana R. Gerner
- Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego
- Daniel Petras
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
- Janet Z. Liu
- Department of Microbiology & Molecular Genetics, University of California Irvine
- Keith D. Green
- Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky
- Sarah L. Price
- Department of Microbiology and Immunology, University of Louisville School of Medicine
- Jose Camacho
- Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego
- Hannah Hillman
- Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego
- Joshua Tjokrosurjo
- Department of Microbiology & Molecular Genetics, University of California Irvine
- Nicola P. Montaldo
- Department of Microbiology & Molecular Genetics, University of California Irvine
- Evelyn M. Hoover
- Department of Microbiology & Molecular Genetics, University of California Irvine
- Sean Treacy-Abarca
- Department of Microbiology & Molecular Genetics, University of California Irvine
- Benjamin A. Gilston
- Department of Biochemistry and Chemistry, and Center for Structural Biology, Vanderbilt University Medical Center
- Eric P. Skaar
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Walter J. Chazin
- Department of Biochemistry and Chemistry, and Center for Structural Biology, Vanderbilt University Medical Center
- Sylvie Garneau-Tsodikova
- Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky
- Matthew B. Lawrenz
- Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, Department of Microbiology and Immunology, University of Louisville School of Medicine
- Robert D. Perry
- Department of Microbiology and Immunology, University of Kentucky
- Sean-Paul Nuccio
- Department of Microbiology & Molecular Genetics, University of California Irvine
- Pieter C. Dorrestein
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
- Manuela Raffatellu
- Department of Microbiology & Molecular Genetics, University of California Irvine
- DOI
- https://doi.org/10.1038/s41467-021-27297-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Zinc is an essential cofactor for bacterial metabolism. Here, the authors show that the probiotic bacterium Escherichia coli Nissle 1917 utilizes the siderophore yersiniabactin as a zincophore, allowing the microbe to grow in zinc-limited media and to thrive in the inflamed gut.
